منابع مشابه
Quantifying GPIIb/IIIa receptor binding using 2 monoclonal antibodies: discriminating abciximab and small molecular weight antagonists.
BACKGROUND Dosing of glycoprotein (GP) IIb/IIIa receptor antagonists is frequently based on the inhibition of platelet aggregation, which may be influenced by the agonist used or concurrent medications. Here we describe a monoclonal antibody-based technique to quantify total and ligand-occupied GPIIb/IIIa receptors. METHODS AND RESULTS In vitro binding of monoclonal antibodies, LYP18 (Mab1) a...
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Some microbial pathogens utilize human complement regulatory proteins, such as factor H (FH) and factor H-like protein 1 (FHL-1), for immune evasion. FbaA is an FHL-1 and FH binding protein expressed on the surface of group A streptococcus (GAS), a common agent of pharyngeal, skin, and soft tissue infections. In this study, we prepared monoclonal antibodies (MAbs) against FbaA, assayed them for...
متن کاملAnti-CCR4 monoclonal antibody enhances antitumor immunity by modulating tumor-infiltrating Tregs in an ovarian cancer xenograft humanized mouse model.
Recent studies have demonstrated that regulatory T cells (Tregs) are recruited to tumor sites where they can suppress antitumor immunity. The chemokine receptor CCR4 is expressed at high levels on functional CD4+CD25+FoxP3+ Tregs and production of the CCR4 ligand CCL22 by tumor cells and tumor-associated macrophages is associated with Treg recruitment to the tumor site. Here, we tested IgG1 and...
متن کاملMonoclonal anti-idiotype induces antibodies against bovine Q17 rotavirus.
This study describes, for the first time, the production and use of an "internal-image" anti-idiotypic monoclonal antibody (MAb) to elicit a rotavirus-specific antibody response. An immunoglobulin G2a MAb, designated RQ31 (MAb1), specific for the outer capsid protein VP4 of bovine Q17 rotavirus and capable of neutralizing viral infection in vitro was used to generate an anti-idiotypic MAb (MAb2...
متن کاملBayesian perspective over time
Thomas Bayes, the founder of Bayesian vision, entered the University of Edinburgh in 1719 to study logic and theology. Returning in 1722, he worked with his father in a small church. He also was a mathematician and in 1740 he made a novel discovery which he never published, but his friend Richard Price found it in his notes after his death in 1761, reedited it and published it. But until L...
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ژورنال
عنوان ژورنال: Cataloging & Classification Quarterly
سال: 2012
ISSN: 0163-9374,1544-4554
DOI: 10.1080/01639374.2012.681600